References
A., Copeland R. 2005. “Evaluation of Enzyme Inhibitors in Drug
Discovery. A Guide for Medicinal Chemists and Pharmacologists.”
Methods of Biochemical Analysis 46: 1–265.
Abella, Anna, Luc Marti, Marta Camps, Marc Claret, J. Fernández-Alvarez,
Ramon Gomis, Anna Gumà, et al. 2003. “Semicarbazide-Sensitive
Amine Oxidase/Vascular Adhesion Protein-1 Activity Exerts an
Antidiabetic Action in Goto-Kakizaki Rats.” Diabetes 52
(April): 1004–13. https://doi.org/10.2337/DIABETES.52.4.1004.
An, Yu A., and Philipp E. Scherer. 2020. “Mouse Adipose Tissue
Protein Extraction.” Bio-Protocol 10 (June). https://doi.org/10.21769/BIOPROTOC.3631.
Arvilommi, Anna Maija, Marko Salmi, and Sirpa Jalkanen. 1997.
“Organ-Selective Regulation of Vascular Adhesion Protein-1
Expression in Man.” European Journal of Immunology 27
(July): 1794–1800. https://doi.org/10.1002/EJI.1830270730.
BARRAND, MARGERY A., SHEILA A. FOX, and BRIAN A. CALLINGHAM. 1984.
“Amine Oxidase Activities in Brown Adipose Tissue of the Rat:
Identification of Semicarbazide‐sensitive (Clorgyline‐resistant)
Activity at the Fat Cell Membrane.” Journal of Pharmacy and
Pharmacology 36: 652–58. https://doi.org/10.1111/j.2042-7158.1984.tb04837.x.
Barrant, M. A., and B. A. Callingham. 1984. “Solubilization and
Some Properties of a Semicarbazide-Sensitive Amine Oxidase in Brown
Adipose Tissue of the Rat.” The Biochemical Journal 222:
467–75. https://doi.org/10.1042/BJ2220467.
Belligoli, Anna, Chiara Compagnin, Marta Sanna, Francesca Favaretto,
Roberto Fabris, Luca Busetto, Mirto Foletto, et al. 2019.
“Characterization of Subcutaneous and Omental Adipose Tissue in
Patients with Obesity and with Different Degrees of Glucose
Impairment.” Scientific Reports 9 (August): 11333. https://doi.org/10.1038/S41598-019-47719-Y.
Blondin, Denis P., Soren Nielsen, Eline N. Kuipers, Mai C. Severinsen,
Verena H. Jensen, Stéphanie Miard, Naja Z. Jespersen, et al. 2020.
“Human Brown Adipocyte Thermogenesis Is Driven by Β2-AR
Stimulation.” Cell Metabolism 32 (August): 287–300.e7.
https://doi.org/10.1016/J.CMET.2020.07.005.
Boomsma, F., P. J. De Kam, G. Tjeerdsma, A. H. Van Den Meiracker, and D.
J. Van Veldhuisen. 2000. “Plasma Semicarbazide-Sensitive Amine
Oxidase (SSAO) Is an Independent Prognostic Marker for Mortality in
Chronic Heart Failure.” European Heart Journal 21:
1859–63. https://doi.org/10.1053/EUHJ.2000.2176.
Börgeson, Emma, Jeremie Boucher, and Carolina E. Hagberg. 2022.
“Of Mice and Men: Pinpointing Species Differences in Adipose
Tissue Biology.” Frontiers in Cell and Developmental
Biology 10 (September): 1003118. https://doi.org/10.3389/FCELL.2022.1003118/BIBTEX.
Bour, Sandy, Sylvie Caspar-Bauguil, Zsuzsa Iffiú-Soltész, Maryse
Nibbelink, Béatrice Cousin, Mari Miiluniemi, Marko Salmi, et al. 2009.
“Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1
Deficiency Reduces Leukocyte Infiltration into Adipose Tissue and Favors
Fat Deposition.” The American Journal of Pathology 174:
1075–83. https://doi.org/10.2353/AJPATH.2009.080612.
Cai, Limeng, Yuqi Wang, Ying Yang, and Hao Wu. 2022. “A Low-Cost,
Enzyme-Coupled Fluorescent Assay for Rapid Quantification of Glycolysis
Rate of Cells.” Analytical and Bioanalytical Chemistry
414 (February): 1987–97. https://doi.org/10.1007/S00216-021-03834-2/METRICS.
Carpéné, Christian, Nathalie Boulet, Alice Chaplin, and Josep Mercader.
2019. “Past, Present and Future Anti-Obesity Effects of
Flavin-Containing and/or Copper-Containing Amine Oxidase
Inhibitors.” Medicines (Basel, Switzerland) 6 (January):
9. https://doi.org/10.3390/MEDICINES6010009.
Chait, Alan, and Laura J. den Hartigh. 2020. “Adipose Tissue
Distribution, Inflammation and Its Metabolic Consequences, Including
Diabetes and Cardiovascular Disease.” Frontiers in
Cardiovascular Medicine 7 (February). https://doi.org/10.3389/FCVM.2020.00022.
Che, Baoquan, Lin Wang, Zhe Zhang, Yongqian Zhang, and Yulin Deng. 2012.
“Distribution and Accumulation of Caffeine in Rat Tissues and Its
Inhibition on Semicarbazide-Sensitive Amine Oxidase.”
NeuroToxicology 33 (October): 1248–53. https://doi.org/10.1016/J.NEURO.2012.07.004.
Chew, Nicholas W. S., Cheng Han Ng, Darren Jun Hao Tan, Gwyneth Kong,
Chaoxing Lin, Yip Han Chin, Wen Hui Lim, et al. 2023. “The Global
Burden of Metabolic Disease: Data from 2000 to 2019.” Cell
Metabolism 35 (March): 414–428.e3. https://doi.org/10.1016/j.cmet.2023.02.003.
Chusyd, Daniella E., Donghai Wang, Derek M. Huffman, and Tim R. Nagy.
2016. “Relationships Between Rodent White Adipose Fat Pads and
Human White Adipose Fat Depots.” Frontiers in Nutrition
3 (April). https://doi.org/10.3389/FNUT.2016.00010.
Danielli, Marianna, Roisin Clare Thomas, Lauren Marie Quinn, and Bee
Kang Tan. 2022. “Vascular Adhesion Protein-1 (VAP-1) in Vascular
Inflammatory Diseases: A Narrative Review.” Vasa - European
Journal of Vascular Medicine 51 (November): 341–50. https://doi.org/10.1024/0301-1526/a001031.
Dezse, K. E., W. P. Frank, and C. A. C. Baptista. 2020. “Fat
Removal During Acetone Dehydration and Defatting Phases of
Plastination.” Journal of Plastination 32: 26–30. https://doi.org/10.56507/MBJO3692.
Dunkel, P., A. Gelain, D. Barlocco, N. Haider, K. Gyires, B. Sperlagh,
K. Magyar, E. Maccioni, A. Fadda, and P. Matyus. 2008.
“Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein
1: Recent Developments Concerning Substrates and Inhibitors of a
Promising Therapeutic Target.” Current Medicinal
Chemistry 15 (July): 1827–39. https://doi.org/10.2174/092986708785133022.
Hernandez-Guillamon, Mar, Lidia Garcia-Bonilla, Montse Solé, Victoria
Sosti, Mireia Parés, Mireia Campos, Arantxa Ortega-Aznar, et al. 2010.
“Plasma VAP-1/SSAO Activity Predicts Intracranial Hemorrhages and
Adverse Neurological Outcome After Tissue Plasminogen Activator
Treatment in Stroke.” Stroke 41: 1528–35. https://doi.org/10.1161/STROKEAHA.110.584623.
Iglesias-Osma, Maria Carmen, Sandy Bour, Maria Jose Garcia-Barrado,
Virgile Visentin, Maria Francisca Pastor, Xavier Testar, Luc Marti, et
al. 2005. “Methylamine but Not Mafenide Mimics Insulin-Like
Activity of the Semicarbazide-Sensitive Amine Oxidase-Substrate
Benzylamine on Glucose Tolerance and on Human Adipocyte
Metabolism.” Pharmacological Research 52 (December):
475–84. https://doi.org/10.1016/J.PHRS.2005.07.008.
Iglesias-Osma, María Carmen, Maria José Garcia-Barrado, Virgile
Visentin, Maria Francisca Pastor-Mansilla, Sandy Bour, Daníelle Prévot,
Philippe Valet, Julio Moratinos, and Christian Carpéné. 2004.
“Benzylamine Exhibits Insulin-Like Effects on Glucose Disposal,
Glucose Transport, and Fat Cell Lipolysis in Rabbits and Diabetic
Mice.” The Journal of Pharmacology and Experimental
Therapeutics 309 (June): 1020–28. https://doi.org/10.1124/JPET.103.063636.
Jarnicki, A. G., H. Schilter, G. Liu, K. Wheeldon, A. T. Essilfie, J. S.
Foot, T. T. Yow, W. Jarolimek, and Philip M. Hansbro. 2016. “The
Inhibitor of Semicarbazide-Sensitive Amine Oxidase, PXS-4728A,
Ameliorates Key Features of Chronic Obstructive Pulmonary Disease in a
Mouse Model.” British Journal of Pharmacology 173:
3161–75. https://doi.org/10.1111/bph.13573.
Karakuzu, Ozgur, Melissa R. Cruz, Yi Liu, and Danielle A. Garsin. 2019.
“Amplex Red Assay for Measuring Hydrogen Peroxide Production from
Caenorhabditis Elegans.” Bio-Protocol 9 (November). https://doi.org/10.21769/BIOPROTOC.3409.
Kurkijarvi, Riikka, Gennady G. Yegutkin, Bridget K. Gunson, Sirpa
Jalkanen, Marko Salmi, and David H. Adams. 2000. “Circulating
Soluble Vascular Adhesion Protein 1 Accounts for the Increased Serum
Monoamine Oxidase Activity Chronic Liver Disease.”
Gastroenterology 119: 1096–1103. https://doi.org/10.1053/gast.2000.18163.
Li, Chaosheng, Zhenhua Wang, Xiaoli Li, and Jun Chen. 2019.
“Effects of Semicarbazide-Sensitive Amine Oxidase Inhibitors on
Morphology of Aorta and Kidney in Diabetic Rats.” BMC
Endocrine Disorders 19 (June). https://doi.org/10.1186/S12902-019-0392-1.
Li, Hui, Shiyu Du, Panpan Niu, Xiaosong Gu, Jun Wang, and Ying Zhao.
2021. “Vascular Adhesion Protein-1 (VAP-1)/Semicarbazide-Sensitive
Amine Oxidase (SSAO): A Potential Therapeutic Target for Atherosclerotic
Cardiovascular Diseases.” Frontiers in Pharmacology 12
(July). https://doi.org/10.3389/FPHAR.2021.679707.
Lyles, G. A. 1995. “Substrate-Specificity of Mammalian
Tissue-Bound Semicarbazide-Sensitive Amine Oxidase.” Progress
in Brain Research 106: 293–303. https://doi.org/10.1016/s0079-6123(08)61226-1.
Ma, Qingyi, Anatol Manaenko, Nikan H. Khatibi, Wanqiu Chen, John H.
Zhang, and Jiping Tang. 2011. “Vascular Adhesion Protein-1
Inhibition Provides Antiinflammatory Protection After an Intracerebral
Hemorrhagic Stroke in Mice.” Journal of Cerebral Blood Flow
and Metabolism : Official Journal of the International Society of
Cerebral Blood Flow and Metabolism 31: 881–93. https://doi.org/10.1038/JCBFM.2010.167.
Manasieva, Vesna, Shori Thakur, Lisa A. Lione, Anwar R. Baydoun, and
John Skamarauskas. 2023. “The Impact of Semicarbazide Sensitive
Amine Oxidase Activity on Rat Aortic Vascular Smooth Muscle
Cells.” International Journal of Molecular Sciences 2023,
Vol. 24, Page 4946 24 (March): 4946. https://doi.org/10.3390/IJMS24054946.
Manasieva, Vesna, Shori Thakur, Lisa A. Lione, Jessal Patel, Anwar
Baydoun, and John Skamarauskas. 2022. “Semicarbazide-Sensitive
Amine Oxidase (SSAO) and Lysyl Oxidase (LOX) Association in Rat Aortic
Vascular Smooth Muscle Cells.” Biomolecules 12
(November). https://doi.org/10.3390/BIOM12111563.
Marin, R. Diaz, S. Crespo-Garcia, Ariel Molly Wilson, and P. Sapieha.
2019. “RELi Protocol: Optimization for Protein Extraction from
White, Brown and Beige Adipose Tissues.” MethodsX 6
(January): 918–28. https://doi.org/10.1016/J.MEX.2019.04.010.
Mercader, Josep, Zsuzsa Iffiú-Soltész, Sandy Bour, and Christian
Carpéné. 2011. “Oral Administration of Semicarbazide Limits Weight
Gain Together with Inhibition of Fat Deposition and of Primary Amine
Oxidase Activity in Adipose Tissue.” Journal of Obesity
2011 (January): 475786. https://doi.org/10.1155/2011/475786.
Murata, Miyuki, Kousuke Noda, Akiko Kawasaki, Shiho Yoshida, Yoko Dong,
Michiyuki Saito, Zhenyu Dong, et al. 2017. “Soluble Vascular
Adhesion Protein-1 Mediates Spermine Oxidation as
Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative
Diabetic Retinopathy.” Current Eye Research 42
(December): 1674–83. https://doi.org/10.1080/02713683.2017.1359847.
Noble, James E., and Marc J. A. Bailey. 2009. “Chapter 8
Quantitation of Protein.” Methods in Enzymology 463
(January): 73–95. https://doi.org/10.1016/S0076-6879(09)63008-1.
Obata, Toshio. 2006. “Diabetes and Semicarbazide-Sensitive Amine
Oxidase (SSAO) Activity: A Review.” Life Sciences 79
(June): 417–22. https://doi.org/10.1016/j.lfs.2006.01.017.
Pannecoeck, Roos, Daphne Serruys, Lara Benmeridja, Joris R. Delanghe,
Nanja Van Geel, Reinhart Speeckaert, and Marijn M. Speeckaert. 2015.
“Vascular Adhesion Protein-1: Role in Human Pathology and
Application as a Biomarker.” Critical Reviews in Clinical
Laboratory Sciences 52: 284–300. https://doi.org/10.3109/10408363.2015.1050714.
Papukashvili, Dimitri, Nino Rcheulishvili, and Yulin Deng. 2020.
“Attenuation of Weight Gain and Prevention of Associated
Pathologies by Inhibiting SSAO.” Nutrients 12. https://doi.org/10.3390/NU12010184.
Peng, Ya, Jun Wang, Miao Zhang, Panpan Niu, Mengya Yang, Yilin Yang, and
Ying Zhao. 2016. “Inactivation of Semicarbazide-Sensitive Amine
Oxidase Stabilizes the Established Atherosclerotic Lesions via Inducing
the Phenotypic Switch of Smooth Muscle Cells.” PloS One
11 (April). https://doi.org/10.1371/JOURNAL.PONE.0152758.
Reddy, Vundrala Sumedha, S. Shiva, Srinidhi Manikantan, and Seeram
Ramakrishna. 2024. “Pharmacology of Caffeine and Its Effects on
the Human Body.” European Journal of Medicinal Chemistry
Reports 10 (April): 100138. https://doi.org/10.1016/J.EJMCR.2024.100138.
Salmi, Marko, and Sirpa Jalkanen. 1992. “A 90-Kilodalton
Endothelial Cell Molecule Mediating Lymphocyte Binding in
Humans.” Science (New York, N.Y.) 257 (September):
1407–9. https://doi.org/10.1126/SCIENCE.1529341.
———. 2019. “Vascular Adhesion Protein-1: A Cell Surface Amine
Oxidase in Translation.” Antioxidants & Redox
Signaling 30 (January): 314. https://doi.org/10.1089/ARS.2017.7418.
Salmi, Marko, Sami Tohka, and Sirpa Jalkanen. 2000. “Human
Vascular Adhesion Protein-1 (VAP-1) Plays a Critical Role in
Lymphocyte-Endothelial Cell Adhesion Cascade Under Shear.”
Circulation Research 86 (June): 1245–51. https://doi.org/10.1161/01.RES.86.12.1245.
Schilter, Heidi C., Adam Collison, Remo C. Russo, Jonathan S. Foot, Tin
T. Yow, Angelica T. Vieira, Livia D. Tavares, Joerg Mattes, Mauro M.
Teixeira, and Wolfgang Jarolimek. 2015. “Effects of an
Anti-Inflammatory VAP-1/SSAO Inhibitor, PXS-4728A, on Pulmonary
Neutrophil Migration.” Respiratory Research 16 (March).
https://doi.org/10.1186/S12931-015-0200-Z.
Silvola, Johanna M. U., Helena Virtanen, Riikka Siitonen, Sanna
Hellberg, Heidi Liljenbäck, Olli Metsälä, Mia Ståhle, et al. 2016.
“Leukocyte Trafficking-Associated Vascular Adhesion Protein 1 Is
Expressed and Functionally Active in Atherosclerotic Plaques.”
Scientific Reports 6 (October). https://doi.org/10.1038/SREP35089.
Stevanato, Roberto, Sara Cardillo, Michele Braga, Angela De Iuliis,
Valentina Battaglia, Antonio Toninello, Enzo Agostinelli, and Fabio
Vianello. 2011. “Preliminary Kinetic Characterization of a Copper
Amine Oxidase from Rat Liver Mitochondria Matrix.” Amino
Acids 40: 713–20. https://doi.org/10.1007/S00726-010-0708-Y.
Sun, Ping, Mar Hernandez-Guillamón, Mireia Campos-Martorell, Alba
Simats, Joan Montaner, Mercedes Unzeta, and Montse Solé. 2018.
“Simvastatin Blocks Soluble SSAO/VAP-1 Release in Experimental
Models of Cerebral Ischemia: Possible Benefits for Stroke-Induced
Inflammation Control.” Biochimica Et Biophysica Acta.
Molecular Basis of Disease 1864 (February): 542–53. https://doi.org/10.1016/J.BBADIS.2017.11.014.
Tábi, Tamás, Éva Szöko, Anita Mérey, Veronika Tóth, Péter Mátyus, and
Klára Gyires. 2013. “Study on SSAO Enzyme Activity and
Anti-Inflammatory Effect of SSAO Inhibitors in Animal Model of
Inflammation.” Journal of Neural Transmission (Vienna,
Austria : 1996) 120 (June): 963–67. https://doi.org/10.1007/S00702-012-0961-1.
Toiyama, Yuji, Chikao Miki, Yasuhiro Inoue, Aya Kawamoto, and Masato
Kusunoki. 2009. “Circulating Form of Human Vascular Adhesion
Protein-1 (VAP-1): Decreased Serum Levels in Progression of Colorectal
Cancer and Predictive Marker of Lymphatic and Hepatic
Metastasis.” Journal of Surgical Oncology 99 (May):
368–72. https://doi.org/10.1002/jso.21246.
Unzeta, Mercedes, Mar Hernàndez-Guillamon, Ping Sun, and Montse Solé.
2021. “SSAO/VAP-1 in Cerebrovascular Disorders: A Potential
Therapeutic Target for Stroke and Alzheimer’s Disease.”
International Journal of Molecular Sciences 2021, Vol. 22, Page
3365 22 (March): 3365. https://doi.org/10.3390/IJMS22073365.
Wang, Shu Huei, Tse Ya Yu, Feng Chiao Tsai, Chris J. Weston, Mao Shin
Lin, Chi Sheng Hung, Hsien Li Kao, et al. 2018. “Inhibition of
Semicarbazide-Sensitive Amine Oxidase Reduces Atherosclerosis in
Apolipoprotein e-Deficient Mice.” Translational Research
197 (July): 12–31. https://doi.org/10.1016/j.trsl.2018.03.001.
Xu, Hao Liang, Maggie Garcia, Fernando Testai, Francesco Vetri,
Alexandra Barabanova, Dale A. Pelligrino, and Chanannait Paisansathan.
2014. “Pharmacologic Blockade of Vascular Adhesion Protein-1
Lessens Neurologic Dysfunction in Rats Subjected to Subarachnoid
Hemorrhage.” Brain Research 1586 (October): 83–89. https://doi.org/10.1016/J.BRAINRES.2014.08.036.
Yan, Liben, Chunli Sun, Yaxi Zhang, Peng Zhang, Yu Chen, Yifan Deng,
Tianyi Er, Yulin Deng, Zhimin Wang, and Hong Ma. 2023. “The
Biological Implication of Semicarbazide-Sensitive Amine Oxidase (SSAO)
Upregulation in Rat Systemic Inflammatory Response Under Simulated
Aerospace Environment.” International Journal of Molecular
Sciences 24 (February): 3666. https://doi.org/10.3390/IJMS24043666/S1.
Yang, Wei, Hui Li, Hongjun Luo, and Wenhong Luo. 2011. “Inhibition
of Semicarbazide-Sensitive Amine Oxidase Attenuates Myocardial
Ischemia-Reperfusion Injury in an in Vivo Rat Model.” Life
Sciences 88 (February): 302–6. https://doi.org/10.1016/J.LFS.2010.12.003.
Yasuda, Hiromi, Yuji Toiyama, Masaki Ohi, Yasuhiko Mohri, Chikao Miki,
and Masato Kusunoki. 2011. “Serum Soluble Vascular Adhesion
Protein-1 Is a Valuable Prognostic Marker in Gastric Cancer.”
Journal of Surgical Oncology 103 (June): 695–99. https://doi.org/10.1002/jso.21877.
Yraola, Francesc, Silvia García-Vicente, Luc Marti, Fernando Albericio,
Antonio Zorzano, and Miriam Royo. 2007. “Understanding the
Mechanism of Action of the Novel SSAO Substrate (C7NH10)6(V10O28)·2H2O,
a Prodrug of Peroxovanadate Insulin Mimetics.” Chemical
Biology & Drug Design 69 (June): 423–28. https://doi.org/10.1111/J.1747-0285.2007.00516.X.
Yu, P. H., and Y. L. Deng. 1998. “Endogenous Formaldehyde as a
Potential Factor of Vulnerability of Atherosclerosis: Involvement of
Semicarbazide-Sensitive Amine Oxidase-Mediated Methylamine
Turnover.” Atherosclerosis 140 (October): 357–63. https://doi.org/10.1016/S0021-9150(98)00142-7.
Yu, Peter H., Michael Wang, Hui Fan, Yulin Deng, and Diana
Gubisne-Haberle. 2004. “Involvement of SSAO-Mediated Deamination
in Adipose Glucose Transport and Weight Gain in Obese Diabetic KKAy
Mice.” American Journal of Physiology - Endocrinology and
Metabolism 286 (April). https://doi.org/10.1152/AJPENDO.00272.2003.
Yu, P., M. Wang, Y. Deng, H. Fan, and L. Shira-Bock. 2002.
“Involvement of Semicarbazide-Sensitive Amine Oxidase-Mediated
Deamination in Atherogenesis in KKAy Diabetic Mice Fed with High
Cholesterol Diet.” Diabetologia 45: 1255–62. https://doi.org/10.1007/S00125-002-0903-9.
Zhang, Miao, Limin Liu, Feng Zhi, Panpan Niu, Mengya Yang, Xuemei Zhu,
Ying Diao, Yanmei Li, Jun Wang, and Ying Zhao. 2016. “Inactivation
of Semicarbazide-Sensitive Amine Oxidase Induces the Phenotypic Switch
of Smooth Muscle Cells and Aggravates the Development of Atherosclerotic
Lesions.” Atherosclerosis 249 (June): 76–82. https://doi.org/10.1016/J.ATHEROSCLEROSIS.2016.03.039.
Zorzano, Antonio, Anna Abella, Luc Marti, Christian Carpéné, Manuel
Palacín, and Xavier Testar. 2003. “Semicarbazide-Sensitive Amine
Oxidase Activity Exerts Insulin-Like Effects on Glucose Metabolism and
Insulin-Signaling Pathways in Adipose Cells.” Biochimica Et
Biophysica Acta - Proteins and Proteomics 1647 (April): 3–9. https://doi.org/10.1016/S1570-9639(03)00039-6.